Locations
1-212-335-0236
Email Us
Join Our Team
Book An Appointment
Call Us
Book Appointment

Some Frequent Searches

Depression Treatment at Principium Psychiatry

Back To Home Page
  • Home
  • Depression Treatment at Principium Psychiatry

A Comprehensive Model of Depression Care

Principium Psychiatry is known for its integrated model of care—uniting psychotherapy, medication management, interventional psychiatry, and precision diagnostics under one roof. Depression rarely stems from a single cause, so we take a multifaceted approach to understanding and treating it.

Our psychiatrists begin with a comprehensive evaluation that looks beyond symptoms to include biological, psychological, and social factors. We then create a personalized treatment plan that may involve one or several of the following modalities:

Psychopharmacology

We use evidence-based medication management to treat major depressive disorder, dysthymia, bipolar depression, and treatment-resistant depression. Our psychiatrists are experts in tailoring antidepressant and mood-stabilizing medications to the individual—minimizing side effects and optimizing outcomes.

Psychotherapy

Our team includes experienced psychotherapists trained in modalities such as Cognitive Behavioral Therapy (CBT), Psychodynamic Therapy, and Interpersonal Therapy (IPT). These approaches help patients recognize and change maladaptive patterns, develop resilience, and reconnect with a sense of meaning and purpose.

Transcranial Magnetic Stimulation (TMS)

Principium Psychiatry is a leader in interventional psychiatry, offering cutting-edge TMS therapy for depression. This non-invasive, FDA-approved treatment uses magnetic pulses to stimulate areas of the brain involved in mood regulation. It is an ideal option for patients who have not found sufficient relief from medication or therapy alone.

Ketamine and Esketamine (Spravato®)

Our clinics in Manhattan, Santa Monica, Greenwich, and the Hamptons are among the few in the country offering both IV ketamine infusions and intranasal Spravato®. Ketamine has shown remarkable success in treating severe and treatment-resistant depression, often producing rapid improvement in mood and functioning. Our protocols are overseen by board-certified psychiatrists who specialize in ketamine’s safe and effective use.at Principium Psychiatry

Electroconvulsive Therapy (ECT)

For select patients with severe depression, psychotic depression, or suicidality, ECT remains one of the most effective and evidence-based treatments available. Our psychiatrists coordinate care with ECT providers to ensure continuity and comprehensive support before, during, and after the procedure.

Genetic and Precision Medicine Testing

We offer pharmacogenetic testing to help identify how your unique genetic profile may affect your response to medications. This precision approach helps us select the right treatment faster and reduce the trial-and-error often associated with medication management.

Why Choose Principium Psychiatry?

Expertise and Leadership

Principium Psychiatry was founded by Dr. Ziv E. Cohen, a board-certified psychiatrist and clinical associate professor at Weill Cornell Medical College. Under Dr. Cohen’s leadership, our clinicians bring together academic excellence, clinical experience, and compassion. Many of our psychiatrists and therapists have advanced training in interventional psychiatry, neuropsychiatry, and psychopharmacology—ensuring that patients receive the highest standard of care.

Integrated, Team-Based Care

At Principium, collaboration is central to our philosophy. Our psychiatrists, psychologists, therapists, and nurse practitioners work together as a team, coordinating treatment plans across specialties and locations. This integrated structure ensures that every patient benefits from collective expertise and seamless communication—whether they’re receiving TMS in Manhattan, psychotherapy in Greenwich, or medication management in Los Angeles.

Advanced Treatments for Treatment-Resistant Depression

Many of our patients come to Principium after trying multiple antidepressants or therapy approaches elsewhere without success. We specialize in treatment-resistant depression (TRD) and offer advanced options including TMS, ketamine, and combination therapy models. Our interventional psychiatry program is one of the most robust in the country—integrating real-time outcome tracking, precision dosing, & long-term maintenance strategies.

Compassion, Confidentiality, and Comfort

We understand that seeking treatment for depression can feel daunting. That’s why we’ve created an atmosphere of warmth, privacy, and professionalism at every location. From your first consultation to your ongoing care, our clinicians take the time to understand your story, answer your questions, and guide you toward recovery at your own pace. Every treatment at Principium is delivered with empathy and respect.

Accessibility Across Regions

We know that continuity matters. That’s why we’ve established offices in key metropolitan and suburban regions, including:

  • New York City (Midtown Manhattan)

    Our flagship location, offering full-spectrum interventional psychiatry.

  • Greenwich, Connecticut

    A serene, discreet environment ideal for patients seeking high-quality outpatient care.

  • Santa Monica, California

    Serving Los Angeles with advanced treatments like Spravato®, ketamine, and TMS.

  • The Hamptons

    Providing seasonal and year-round psychiatric care with the same level of excellence as our urban clinics.

  • Garden City, Long Island

    Personalized psychiatric care for individuals and families looking for exceptional treatment close to home in Garden City, Long Island.

Patients often travel between these locations, and Principium’s unified electronic records and care protocols allow for continuity across state lines. You can begin treatment in Manhattan, continue follow-up visits in Santa Monica or Greenwich, and expect the same exceptional standard of care throughout.

Depression We Treat

Principium Psychiatry treats the full spectrum of depressive disorders, including:

  • Major Depressive Disorder (MDD)
  • Persistent Depressive Disorder (Dysthymia)
  • Bipolar Depression
  • Seasonal Affective Disorder
  • Postpartum Depression
  • Depression with Anxiety
  • Treatment-Resistant Depression

Our approach is evidence-based and personalized. We recognize that depression often overlaps with anxiety, trauma, or medical conditions, and we tailor treatment accordingly. Our psychiatrists frequently collaborate with primary care physicians, neurologists, and other specialists to ensure comprehensive care.

A Science-Based, Hope-Driven Philosophy

At Principium Psychiatry, science and empathy go hand in hand. We believe that no patient should settle for partial improvement. Our approach is to measure outcomes, optimize treatments, and restore hope—even for those who have struggled for years.

Each patient’s care plan evolves over time, guided by progress and feedback. We combine traditional psychiatry with the most innovative technologies and therapies available today. Whether your depression is mild, moderate, or severe, Principium provides the tools and expertise to help you achieve full remission and sustained well-being.

Serving New York, Los Angeles, Connecticut, Garden City, and the Hamptons

Our multi-state presence allows us to serve patients wherever they live or travel. Each office reflects the same principles of clinical excellence, discretion, and warmth.

  • New York City (Midtown Manhattan)

    Centrally located and easily accessible to residents across Manhattan and surrounding boroughs.

  • Greenwich, Connecticut

    Convenient to Fairfield and Westchester counties, offering privacy and convenience for local professionals and families.

  • Santa Monica, Los Angeles

    Combining coastal calm with clinical sophistication, serving patients from Santa Monica, Brentwood, and Beverly Hills.

  • The Hamptons

    Providing access to psychiatric expertise for residents and seasonal visitors in East Hampton, Southampton, and surrounding towns.

  • Garden City, Long Island

    Comprehensive, patient-centered psychiatric services delivered with excellence in the heart of Garden City on Long Island.

Why Principium Is the Best Choice for Depression Treatment

Principium Psychiatry stands apart because of our integration of evidence-based medicine, advanced technology, and individualized human care. Our multi-disciplinary team delivers world-class treatment in accessible, beautifully designed settings across four regions. We treat the person, not just the disorder—offering real hope and real results.

If you or a loved one are struggling with depression, you don’t have to face it alone. Principium Psychiatry offers expert, compassionate, and cutting-edge depression care in New York City, Los Angeles, Connecticut, Garden City, and the Hamptons.

Contact us today

to schedule a consultation and begin your path toward recovery.

www.principiumpsychiatry.comBook an Appointment