Physician-Led Psychiatry for Complex Conditions
For patients who have not responded to standard treatments. Care includes advanced medication management and interventional psychiatry (ketamine, TMS, ECT).
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Specialized Care for Complex and Treatment-Resistant Conditions
Principium Psychiatry is a physician-led practice focused on patients whose conditions have not improved with standard treatment. Our approach emphasizes careful diagnosis, structured treatment planning, and the integration of advanced modalities when indicated, including medication strategies and interventional psychiatry. We work closely with patients and referring physicians to provide clear, coordinated care in complex clinical situations.
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Comprehensive Psychiatric Care, Structured Around Complexity
Our practice is organized around the evaluation and treatment of complex psychiatric conditions. Care begins with a detailed diagnostic assessment, followed by a structured treatment plan that may include advanced medication strategies and, when indicated, interventional psychiatry such as TMS, ketamine, or ECT. We emphasize clarity, coordination, and continuity of care, working closely with patients and referring physicians to manage conditions that have not improved with standard approaches.
Psychiatric Evaluation & Treatment
Psychopharmacology involves using medication to treat mental disorders. Our pharmacologists in Manhattan will work closely with you to find a medication that improves your symptoms while minimizing side effects. Patients seeking medication therapy typically visit us once per month or more frequently, as needed.
Learn More About Our Psychopharmacology Services Ketamine Therapy
In this pioneering treatment for depression and other mood disorders, patients receive a small dose of the anesthetic ketamine through an IV infusion. Each treatment takes approximately one hour. Because IV ketamine therapy is not yet approved by the U.S. Food and Drug Administration (FDA), it is typically recommended for patients with persistent symptoms that haven’t responded to other treatment options. Intranasal ketamine (Spravato) has FDA approval for the treatment of depression. For those who prefer intra-nasal to IV ketamine, we provide this treatment in the comfort of our office.
Learn More About Our Ketamine Therapy Services Transcranial Magnetic Stimulation
Transcranial Magnetic Stimulation (TMS) treats major depression using a magnetic field to induce stimulation in targeted parts of the brain associated with depression, causing neurons (brain cells) to become more active. TMS is FDA-approved and recommended by the American Psychiatric Association. Treatment occurs over 4-6 weeks, with individual sessions ranging from 20 minutes to one hour in length. Patients stay awake during treatment and typically feel no discomfort and can immediately resume normal activities.
Learn More About Our TMS Services Electroconvulsion Therapy
At Principium Psychiatry, we offer state of the art, cutting edge Electroconvulsive Therapy (ECT) for depression and other conditions. This treatment is provided in a private, state of the art treatment center on Park Avenue, where comfort, privacy, and safety are a priority. Principium Psychiatry’s team collaborates with a top tier anesthesia team to ensure that the treatment is comfortable and safe.
Learn more About Our ECT ServicesPhysician Leadership
Dr. Ziv Cohen
MD Psychiatrist, Founder and Medical Director
Specialization: Psychiatrist
Dr. Cohen leads Principium Psychiatry with a focus on complex and treatment-resistant psychiatric conditions. His clinical work centers on diagnostic clarity and structured treatment planning in cases where prior approaches have not been effective. He regularly collaborates with referring physicians on challenging presentations requiring advanced medication strategies and interventional treatments. The practice is structured around physician-directed care under his leadership.
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Daniel Santarsieri
MD Psychiatrist, Director of Clinical Services
Specialization: Psychiatrist
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Anna Higgins
NP Psychiatric Nurse Practitioner
Specialization: TMS
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Rivka Moskowitz
NP Psychiatric Nurse Practitioner
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Ashley Barnes
NP Psychiatric Nurse Practitioner
Specialization: Psychopharmacology
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Trevor Murray, PMHNP
Psychiatric Mental Health Nurse Practitioner (PMHNP)
Specialization: Psychiatric Nurse Practitioner
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Crystal Persky, PMHNP
Psychiatric Mental Health Nurse Practitioner (PMHNP)
Specialization: Psychiatric Mental Health Nurse Practitioner
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Angela Freker, LMSW
Licensed Master Social Worker
Specialization: Psychotherapist
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Juliette Guetta
LCAT-LP, Licensed Creative Arts Therapist
Specialization: Art Therapy, Psychotherapy
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Interventional Treatments
At Principium Psychiatry, we offer state of the art, cutting edge Electroconvulsive Therapy (ECT) for depression and other conditions. This treatment is provided in a private, state of the art treatment center on Park Avenue, where comfort, privacy, and safety are a priority. Principium Psychiatry’s team collaborates with a top tier anesthesia team to ensure that the treatment is comfortable and safe.
Ketamine is a cutting-edge psychiatric treatment being used to target severe medication and treatment resistant depression. Ketamine has been widely used as an anesthetic for minor procedures since the 1960s. In many countries, it is used by first aid response workers when dealing with minor trauma. The safety of Ketamine is such that it is used as outpatient anesthetic by non-physicians. The dose used to treat depression is about one quarter (1/4) of anesthetic dose.
The first line of treatment for depression and other mood disorders typically involves a combination of medication and talk therapy. This treatment strategy proves effective for many people. However, some patients may experience troublesome side effects or have persistent symptoms that fail to respond to treatment.
Every individual’s experience with depression is different, and as a result, experiences with depression treatments vary. At Principium Psychiatry, we believe everyone deserves access to the mental health care they need to feel better. That’s why, in addition to traditional psychotherapy and psychopharmacology, we offer innovative treatment options like Transcranial Magnetic Stimulation (TMS).
Intensive Outpatient Programs are structured mental health treatment programs designed to provide therapeutic support to individuals with mood and anxiety disorders. IOPs are distinct from inpatient programs because patients do not require 24/7 hospitalization. Instead, they attend regular therapy sessions, group counseling, and educational workshops while living at home or in supportive environments.
What Our Patients Say
Dr. Cohen and his team are so fantastic! They did everything they could to make me feel comfortable, and I started feeling better after the first dose of Ketamine!
The treatment was so much more comfortable than I thought it would be. I experienced slight discomfort during the first two treatments, but it was smooth sailing from then on!
The suite in which I received the treatment was comfortable and welcoming. I was able to relax during the treatments and each time I left, I felt more at peace.
Before starting TMS, I was so depressed that I couldn’t eat, sleep or get out of bed. I had stopped doing the things I enjoyed entirely, because I didn’t have the energy or interest. It took a few weeks, but I started to notice myself thinking more positively, and it kept improving from there. Thank you, Dr. Cohen!
I am so thankful to Dr. Cohen and his team! Thanks to them and the Ketamine treatment, I’m feeling better than I have in years. I was pleasantly surprised that there were no side effects.
My depression improved dramatically throughout the course of my TMS treatment. I am finally able to sleep through the night and I am looking forward to living my life again. My entire family noticed the difference in me before I did. TMS changed my life after decades of failed medications and terrible side effects. I finally feel like “me” again.
Ready to Get Started?
Please fill out the request form below and a team member will be in touch to confirm and schedule your appointment. Please allow 24 hours for us to confirm your appointment. Thank you!
We will confirm the appointment time upon booking completion and we strive to accommodate your ideal time selection. Based on availability we might need to schedule a different time from what is selected.